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Monday, October 21 • 11:50am - 12:10pm
Enabling Technologies- Human Engineered Heart Tissue – An Innovative Model for Preclinical Cardiac Assessment

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The presentation will focus on Engineered Heart Tissue technology (EHT). EHTs are three-dimensional, force-generating cardiac tissues in 24 well-format which are generated from single cell suspensions of human induced pluripotent stem cell-derived cardiomyocytes. EHTs are developed between flexible silicone posts under auxotonic stretch. Automated test platforms will be introduced to analyze physiological parameter like contractile force and calcium transients under standardized conditions based on video-optical recording. Specific aspects related to cardiomyocyte maturation and application for in vitro cardiac assessment of compounds will be addressed.


Arne Hansen, M.D.

Associate Professor, Department for Experimental Pharmacology and Toxicology, UKE/Hamburg
Arne Hansen received his MD at the University of Hamburg. After clinical training and a 3-year PostDoc at NIH he joined the Department for Experimental Pharmacology and Toxicology at UKE/Hamburg in 2007 and was appointed as Assistant Professor in 2012 and Associate Professor in 2018... Read More →

avatar for Hazel Screen, Ph.D., MRes, BEng

Hazel Screen, Ph.D., MRes, BEng

Professor of Biomedical Engineering, Queen Mary University of London
Hazel Screen is Professor of Biomedical Engineering and Chair of Bioengineering at Queen Mary University of London.Her research group focuses on multi-scale structure-function behaviour and mechanobiology in tissues. She has particular interest in in vitro models to explore health... Read More →

Monday October 21, 2019 11:50am - 12:10pm BST
Wellcome Auditorium