Loading…
Go to symposium website → www.slas.org/HighContentAnalysis
Monday, October 21 • 4:30pm - 4:50pm
High-Throughput 3D Cellular Models- Medium-scale Comparative Study of 2D vs. 3D Models Using High Content Imaging Approaches.

Sign up or log in to save this to your schedule and see who's attending!

3D cellular models represent a fantastic opportunity for pharmaceutical industries to improve their discovery pipeline efficacy by bringing potentially much more relevant models within the early stages of the workflow. Moreover, it has been shown that in specific cases 2D and 3D models response to drug treatment can strongly vary and thus impact the in vitro relevance of the physiopathological model associated readouts. This approach is particularly well suited for complex or partially characterized targets in oncology. In this context, we have performed a systematic comparison of the 2D vs. 3D high content imaging readouts using a single cancer cell line. We will discuss about the challenges associated to such large scale screening in term of cellular processing but also in term of image and data analysis. Ultimately, we will discuss about the results generated from such a comparative study.

Speakers
avatar for Thierry Dorval, Ph.D.

Thierry Dorval, Ph.D.

Head of Data Science Lab, Servier
Thierry Dorval received a B.S. degree in theoretical physic and obtained a Ph.D. in image processing and artificial intelligence at Pierre & Marie Curie University, Paris, France. He then joined the Institut Pasteur Korea in 2005 first as researcher in biological image analysis then... Read More →

Chair

Monday October 21, 2019 4:30pm - 4:50pm
Wellcome Auditorium