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Monday, October 21 • 5:10pm - 5:30pm
High-Throughput 3D Cellular Models-Patient Derived Scaffold (PDS) - A Platform for Optimised In Vivo Like Cancer Research and Clinical Testing

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Cancer cells are surrounded and actively interact with the microenvironment at the primary site of growth as well as metastatic niches. Key components in the cancer environment have been linked to various aggressive cancer features and can further influence the essential subpopulation of cancer stem cells most likely governing malignant properties and treatment resistance. In order to model and specifically enumerate the influence of a specific cancer microenvironment we have developed a cell culture platform using cell free scaffolds from cancer samples infiltrated with standardized cancer cells. This in vivo like growth system induced a series of orchestrated changes in differentiation, EMT and proliferation of the cancer population with a final noticeable cancer stem cell expansion as defined by several surrogate assays and functional tests. The developed scaffold model system has a potential to optimally mimic in vivo like growth conditions reveling hidden and highly relevant clinical information about the malignancy inducing property of the specific scaffold earlier surrounding and indeed influencing cancer progressing properties. The platform can be utilized as a diagnostic tool, research instrument and in vivo mimic within screening program as will be further elaborated in the presentation.

Speakers
avatar for Goran Landberg, MD, Ph.D.

Goran Landberg, MD, Ph.D.

Professor, University of Gothenburg
Göran Landberg is professor and senior consultant in pathology focusing on molecular pathology and breast cancer. He has established several national and international centers focusing on cancer research both in Sweden and in England. In total, he has published more than 170 articles... Read More →

Chair

Monday October 21, 2019 5:10pm - 5:30pm
Wellcome Auditorium