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Monday, October 21 • 4:50pm - 5:10pm
High-Throughput 3D Cellular Models- Single-Cell Imaging and Advanced Image Analysis of Primary Tumors for Anticancer Therapy Development

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The ability to perform high-content screening in a high-throughput fashion is routinely limited to cell lines and other explant model systems, however, there is a risk that these may not be fully representative of the in vivo environment due to culture adaptation or the lack of multi-lineage cell types. The ability to gather high-content data directly from primary samples however, both direct from blood and bone marrow or from metastasized cancers, without cell outgrowth or selection in a method amenable to laboratory automation can be a more direct system. Further, by combining imaging of these primary sample with an analysis pipelines robust to micro-aggregates, vastly different cell shapes and sizes, and that can ultimately harness the features from each cell can become a powerful means to study drug response in a variety of indications using model systems directly derived from the patient. This methodology has been used to prioritize therapy for late-state patients with hematological cancers in a basket trial (Snijder & Vladimer et al 2017,Lancet Hematology), has been integrated with genetic data to further uncover biological understanding and clinical synergy options (Schmidl & Vladimer et al 2019, Nat Chem Bio), and is now robustly being tested in technical validation studies for some indications to understand its potential use as an in vitro diagnostic.

avatar for Gregory Vladimer, Ph.D.

Gregory Vladimer, Ph.D.

CSO, Allcyte
Gregory Vladimer is the CSO of Allcyte, a startup in Vienna, Austria. He received his PhD from UMass Medical School where he studied inflammation, and was a Senior Postdoctoral Fellow at CeMM in Vienna. Together with the Department of Hematology of the MedUniWien, spearheaded the... Read More →


Monday October 21, 2019 4:50pm - 5:10pm BST
Wellcome Auditorium