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Tuesday, October 22 • 9:00am - 10:30am
Vendor Workshop - MIMETAS and Molecular Devices - Developing High-Throughput Organ-On-A-Chip Tissue Models for Drug Discovery and Unlocking their Full Potential Using High-Content Imaging

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Organ-on-a-Chip technology is a new paradigm in drug testing. The aim of this technology is to raise the physiological relevance of traditional cell culture by combining it with microfluidic techniques. Organs-on-a-Chip are 3D tissues that capture the complexity of in vivo tissues including 3D morphology, extracellular matrix embedment, multiple cell types, vascular structure and perfusion flow. Incorporating these technologies in a microplate format enables increased throughput in high content imaging systems.

In this presentation, experts from MIMETAS and Molecular Devices will introduce the culture and interrogation of complex 3D tissues, such as liver, kidney, gut and brain tissue. The tissues are grown in the OrganoPlate®, an in vitro cell culture microplate platform that allows culturing of over 40 tissues in parallel. The tissues are embedded in an extracellular matrix gel and comprise both stromal tissue, blood vessel structures as well as epithelial barriers. We will show examples of Organ-on-a-Chip tissues for use in disease modelling and drug safety testing and will present the new OrganoPlate® Graft, which allows vascularization of spheroids, organoids and PDX explants, and offers a powerful solution for the study of angiogenesis, an important focus for cancer therapeutics.

These complex 3D tissue cultures can be interrogated in a high-throughput manner using powerful cellular imaging systems. We will show how Molecular Device’s ImageXpress Micro Confocal High-Content Imaging System and ImageXpress Pico Automated Cell Imager play a vital role in the development and analysis of 3D tissue models, such as those built on the OrganoPlate® platform.

Tuesday October 22, 2019 9:00am - 10:30am BST