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Monday, October 21 • 2:30pm - 3:00pm
Poster Presentation #10- Phenotypic Screening in 3D Culture Including the Extracellular Matrix

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Ninety percent of potential drug candidates fail within the clinical trials, mainly because of a lack of efficacy. Biologists and pharmacologists now largely acknowledge the lack of relevant in vitro models in the early drug development stages.

To mimic human tissues, several parameters need to be taken into account: the target cells but also the extra-cellular matrix (ECM). The ECM has diverse and crucial roles as anchorage of the cells, migration barrier and track, signal reservoir, low-affinity co-receptor, signal presenter and is a source of biochemical forces. All these roles of the matricial micro-environment are really important in maintaining organ’s homeostasis and proper intercellular communications. Depending on the organ, ECM composition and physicochemical properties are different.

Cellular assays in 3D culture have shown many advantages to better mimic in vivo situation. Nevertheless, 3D technology used for phenotypic screening is often really simple, as the use of ULA plates. But we can go further by using 3D technologies, which allow reproducing the microenvironment of healthy or pathological organ of interest, as BIOMIMESYS technology. During this talk, we will see how the cellular microenvironment impacts the proliferation and/or differentiation of cells. Few examples will be presented in oncology, CNS and metabolic diseases fields.

Speakers
NM

Nathalie Maubon, Ph.D.

President, HCS Pharma
With 22 years of experience in the pharmaceutical research (public research, pharmaceutical industry and biotechnology company), Nathalie Maubon is a specialist in the development and automation of robust models for high-throughput screening (HCS, HTS, ADMET). She has held several... Read More →


Monday October 21, 2019 2:30pm - 3:00pm
Sherry Coutu Seminar Suite Foyer