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avatar for Lucas Dent

Lucas Dent

Institute of Cancer Research
Postdoctoral Fellow
United Kingdom
My research aims to understand the signalling networks controlling cell shape and adhesion during normal development, and how these are altered in disease. To do this, my approach is to combine Drosophila (fruit fly) genetics and mammalian (human) systems to reveal the broad principles and mechanistic details of adhesion signalling, respectively.

I completed doctoral studies in 2015 at the Peter MacCallum Cancer Centre in Melbourne, Australia, where I described control of tissue growth, cell shape, and organ development by integrin adhesion signalling proteins in Drosophila. In 2018 I was awarded a Commonwealth Rutherford Fellowship to study cell shape and adhesion with Professor Chris Bakal, at the Institute of Cancer Research in London. In my work with Professor Bakal, we are combining high-throughput and high-content imaging to uncover adhesion signalling networks and use this information to improve targeted therapies in cancer.