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Somaieh Hedayat

Institute of Cancer research
Ph.D. student
Patient-derived organoids (PDOs) have recently emerged as robust preclinical models. We have recently shown that PDOs from metastatic, heavily pretreated, colorectal and gastroesophageal cancer patients mirror the phenotype and the genotype of their parental biopses and recapitulate clinical responses observed in patients. The combined use of PDOs, PDO-xenotransplants and ex vivo PDO co-cultures has the potential to accelerate drug discovery and improve patients’ selection in early phase clinical trials. My research project focuses on the role of tissue microenvironment in modulating sensitivity and resistance to therapy in metastatic Colorectal Cancer (mCRC).